反应详情

2-Fluoro-4-pyridinemethanol (508.5 mg, 4.00 mmol), t-butyldimethylsilylchloride (1.21 g, 8.00 mmol) and imidazole (1.09 g, 16.00 mmol) were stirred in dichloromethane (10 mL) at room temperature for an hour. After completion of the reaction, the reaction solution was mixed with ethyl acetate, and the resulting organic layer was washed with saturated aqueous ammonium chloride, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1) to give the desired product (785.2 mg, 81% yield).

1. customAfter completion of the reaction
2. washthe resulting organic layer was washed with saturated aqueous ammonium chloride
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated under reduced pressure
5. customThe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1)