Ammonium Chloride → HCID 59574603, compound

3-Chloro-2-fluoropyridine-4-carbaldehyde (56.1 mg, 0.35 mmol) in tetrahydrofuran (2 mL) was mixed with methylmagnesium bromide (0.98 M in tetrahydrofuran, 1.13 mL, 1.05 mmol) under −78° C., and the reaction mixture was warmed slowly to room temperature for 16 hours with stirring. After completion of the reaction, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting crude reaction product containing the desired product was used for the next step (64.7 mg).

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. dry with materialthe organic layer was dried over anhydrous sodium sulfate
4. customevaporated under reduced pressure
5. customThe resulting crude reaction product

ORD record

ord-aa6c34562f314e3dafda66c497b752fa

Source dataset

uspto-grants-2013_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08440666B2