bicyclo[3.3.1]non-6-en-3-amine → HCID 21522752, compound

HRID 2092050Notes

Reaction equation

HRID 2092050 reaction equation
[CH:1]12[CH2:9][CH:5]([CH:6]=[CH:7][CH2:8]1)[CH2:4][CH:3]([NH2:10])[CH2:2]2.[H][H]>C(O)C.[C].[Pd]>[CH:1]12[CH2:9][CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH:3]([NH2:10])[CH2:2]2

Participants

5

Reactant 2

HCID 424483bicyclo[3.3.1]non-6-en-3-amineHCID 178418361HCID 178418361, compound

Product 1

HCID 21522752HCID 21522752, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To bicyclo[3.3.1]non-6-en-3-amine (100 mg, 0.729 mmol) in ethanol (3 mL), 10% palladium-carbon (10 mg) was added in a nitrogen stream, and the reaction solution was stirred in a hydrogen stream at room temperature for 1 day. After completion of the reaction, the reaction solution was filtered through celite and the filtrate was evaporated under reduced pressure. The resulting crude reaction product was used for the next step without to further purification (98.5 mg).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe reaction solution was filtered through celite
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe resulting crude reaction product
  5. customwas used for the next step without to further purification (98.5 mg)

Sources & evidence

ORD record
ord-f784df98c5134ac89cb941fe2a3c653a
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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