HCID 68429305, compound → HCID 68432017, compound

HRID 2092075Notes

Reaction equation

HRID 2092075 reaction equation
Br[C:2]1[C:3](=[O:19])[NH:4][N:5]=[CH:6][C:7]=1[NH:8][C@@H:9]1[CH2:14][C@@H:13]2[CH2:15][C@@H:11]([C:12]2([CH3:17])[CH3:16])[C@H:10]1[CH3:18].[H][H]>CO.[C].[Pd]>[CH3:18][C@H:10]1[C@H:9]([NH:8][C:7]2[CH:6]=[N:5][NH:4][C:3](=[O:19])[CH:2]=2)[CH2:14][C@@H:13]2[CH2:15][C@H:11]1[C:12]2([CH3:16])[CH3:17]

Participants

5

Reactant 2

HCID 68429305HCID 68429305, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68432017HCID 68432017, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

4-Bromo-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one (300 mg, 0.92 mmol) and 10% palladium-carbon (50 wt %, 30 mg) in methanol were stirred in a hydrogen stream at room temperature for 1 day. The reaction solution was filtered through celite, and the filtrate was concentrated to give the desired product (100% yield).

Workup

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-1a15f9a2f7084d82a6440d342cea927c
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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