Hydrochloric Acid → HCID 68432311, compound

Participants

Reaction Steps

Ethyl 2-({[5-chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl]acetyl}amino)butyrate (64 mg, 0.145 mmol) in 1,4-dioxane (2 mL) was stirred with 1 M aqueous sodium hydroxide (435 μL, 0.435 mmol) at room temperature for 2 hours. After completion of the reaction, the reaction solution was neutralized with 1 M hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product.

Provenance & Evidence