Hydrochloric Acid → HCID 68432311, compound

HRID 2092107Notes

Reaction equation

HRID 2092107 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH:13]([CH2:19][CH3:20])[C:14]([O:16]CC)=[O:15])=[O:11])[N:5]=[CH:4][C:3]=1[NH:21][C@@H:22]1[CH2:27][C@@H:26]2[CH2:28][C@@H:24]([C:25]2([CH3:30])[CH3:29])[C@H:23]1[CH3:31].[OH-].[Na+].Cl>O1CCOCC1>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH:13]([CH2:19][CH3:20])[C:14]([OH:16])=[O:15])=[O:11])[N:5]=[CH:4][C:3]=1[NH:21][C@@H:22]1[CH2:27][C@@H:26]2[CH2:28][C@@H:24]([C:25]2([CH3:29])[CH3:30])[C@H:23]1[CH3:31]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68431374HCID 68431374, compound

Product 1

HCID 68432311HCID 68432311, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Ethyl 2-({[5-chloro-6-oxo-4-{[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]amino}pyridazin-1(6H)-yl]acetyl}amino)butyrate (64 mg, 0.145 mmol) in 1,4-dioxane (2 mL) was stirred with 1 M aqueous sodium hydroxide (435 μL, 0.435 mmol) at room temperature for 2 hours. After completion of the reaction, the reaction solution was neutralized with 1 M hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to give the desired product.

Workup

  1. customAfter completion of the reaction
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract was dried over anhydrous magnesium sulfate
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-55dd884ca9094ce9a228d6d23796c7dd
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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