Hydrochloride methanol → HCID 68429239, compound

HRID 2092121Notes

Reaction equation

HRID 2092121 reaction equation
[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[O:11])[N:5]=[CH:4][C:3]=1[NH:20][CH:21]1[CH:28]2[CH2:29][CH:24]3[CH2:25][C:26]([O:31]COC)([CH2:30][CH:22]1[CH2:23]3)[CH2:27]2.[ClH:35].CO>>[ClH:35].[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[O:11])[N:5]=[CH:4][C:3]=1[NH:20][CH:21]1[CH:22]2[CH2:23][CH:24]3[CH2:25][C:26]([OH:31])([CH2:27][CH:28]1[CH2:29]3)[CH2:30]2

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 59574457HCID 59574457, compound

Product 1

HCID 68429239HCID 68429239, compoundYield 51%

Procedure

2-[5-Bromo-4-{[5-(methoxymethoxy)tricyclo[3.3.1.13,7]dec-2-yl]amino}-6-oxopyridazin-1(6H)-yl]-N-(pyridin-4-ylmethyl)acetamide (30 mg, 0.0563 mmol) in 10 mass % hydrogen chloride-methanol (3 mL) was stirred at room temperature for 1 hour. After completion of the reaction, the reaction solution was evaporated under reduced pressure, and the resulting solid was collected by filtration and dried to give the desired product (51% yield).

Workup

  1. customAfter completion of the reaction
  2. customthe reaction solution was evaporated under reduced pressure
  3. filtrationthe resulting solid was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-75835a35b1074c7e975165d1b7455dd9
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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