HCID 67236455, compound → HCID 11638123, compound

HRID 2092165Notes

Reaction equation

HRID 2092165 reaction equation
COC([N:5]1[C:13]2[C:8](=[C:9]([NH:14][C:15]([NH:17][CH:18]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[O:21][CH2:20][CH2:19]3)=[O:16])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6]1)=O.COC(N1C2C(=C(NC(NC3C4C(=CC(C(C)(C)C)=CC=4)OCC3)=O)C=CC=2)C=N1)=O>O>[O:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:18]([NH:17][C:15]([NH:14][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:8]=2[CH:7]=[N:6][NH:5]3)=[O:16])[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 67236455HCID 67236455, compoundHCID 67236640HCID 67236640, compound

Product 1

HCID 11638123HCID 11638123, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared according to the procedure as described in Example 1E, substituting the product of Example 16C for the product of Example 1D. 1H NMR (300 MHz, DMSO-d6) δ 13.00 (broad s, 1H), 8.58 (s, 1H), 8.03 (s, 1H), 7.65 (d, J=7.5 Hz, 1H), 7.30 (d, J=7.5 Hz, 1H), 7.20 (m, 2H), 7.05 (d, J=6 Hz, 1H), 6.95-6.80 (m, 3H), 4.90 (m, 1H), 4.30-4.17 (m, 2H), 2.20-2.00 (m, 2H). MS (DCI) m/e 309 (M+H)+. Calcd. For C17H16N4O2.0.6; H2O: C, 63.98; H, 5.43; N, 17.56. Found: C, 63.85; H, 5.07; N, 17.62.

Sources & evidence

ORD record
ord-f6937ce50c2a4cbbaa2ed15b24e3966a
Source dataset
uspto-grants-2013_05
Patent number
US08440691B2

Reaction notes

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