3,4-dihydro-2H-1-benzopyran-3-amine hydrochloride → 2-Aminochroman

HRID 2092176Notes

Reaction equation

HRID 2092176 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)OC1.[C:13](=[O:16])(O)[O-].[Na+]>>[NH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:13](=[CH:6][CH:7]=[CH:8][CH:9]=2)[O:16]1

Participants

3

Reactant 2

HCID 2057083,4-dihydro-2H-1-benzopyran-3-amine hydrochlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 206278382-Aminochroman

Procedure

3-aminochroman hydrochloride (0.37 g, 2 mmol) was neutralized with aqueous sodium bicarbonate, extracted with diethyl ether, dried with magnesium sulfate, and the solvent evaporated to give 2-aminochroman.

Workup

  1. extractionextracted with diethyl ether
  2. dry with materialdried with magnesium sulfate
  3. customthe solvent evaporated

Sources & evidence

ORD record
ord-6c2d2e3d05e04fe18c5edec5546d3a87
Source dataset
uspto-grants-2013_05
Patent number
US08440691B2

Reaction notes

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