HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2092191Generated: October 30, 2026
Potassium Carbonate → (3aS,6aS)-ethyl 1-(3-(phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
https://huagongshe.com/reaction/2092191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Fluoro-3-(phenylsulfonyl)quinoline | HCID 16223766 | — |
| Reactant | (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (2R,3R)-2,3-bis(benzoyloxy)succinate | HCID 86647686 | — |
| Solvent | Sodium Chloride | HCID 5234 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (3aS,6aS)-ethyl 1-(3-(phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate | HCID 25196275 | — |
Reaction Steps
A solution of 8-fluoro-3-(phenylsulfonyl)quinoline (100 mg, 0.348 mmol), (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (2R,3R)-2,3-bis(benzoyloxy)succinate (944 mg, 1.74 mmol) and K2CO3 (577 mg) in DMF (3 mL) was stirred under nitrogen and heated at 100° C. for 7 h. The cooled mixture was diluted with 10 mL of saturated NaCl and the resultant precipitate collected and dried to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440694B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-874a00e2a0da44fb97eb12c9a202baab |
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| Source note | uspto-grants-2013_05 |
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