HRID2092191

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID16223766

未命名化合物

结构：CCOC(=O)N1C[C@@H]2CCN[C@@H]2C1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1

HCID86647686

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)N1C[C@@H]2CCN(c3cccc4cc(S(=O)(=O)c5ccccc5)cnc34)[C@@H]2C1

HCID25196275

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID5234

Sodium chloride

ClNa

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

A solution of 8-fluoro-3-(phenylsulfonyl)quinoline (100 mg, 0.348 mmol), (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (2R,3R)-2,3-bis(benzoyloxy)succinate (944 mg, 1.74 mmol) and K2CO3 (577 mg) in DMF (3 mL) was stirred under nitrogen and heated at 100° C. for 7 h. The cooled mixture was diluted with 10 mL of saturated NaCl and the resultant precipitate collected and dried to give the title compound.

WORKUP

后处理

customthe resultant precipitate collected
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-874a00e2a0da44fb97eb12c9a202baab
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08440694B2
来源说明: uspto-grants-2013_05

反应 SMILES

F[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])=[CH:7]2.C(O[C@H]([C@@H](OC(=O)C1C=CC=CC=1)C(O)=O)C(O)=O)(=O)C1C=CC=CC=1.[NH:47]1[CH2:51][CH2:50][C@H:49]2[CH2:52][N:53]([C:55]([O:57][CH2:58][CH3:59])=[O:56])[CH2:54][C@@H:48]12.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.[Na+].[Cl-]>[C:15]1([S:12]([C:8]2[CH:9]=[N:10][C:11]3[C:6]([CH:7]=2)=[CH:5][CH:4]=[CH:3][C:2]=3[N:47]2[CH2:51][CH2:50][C@H:49]3[CH2:52][N:53]([C:55]([O:57][CH2:58][CH3:59])=[O:56])[CH2:54][C@@H:48]23)(=[O:14])=[O:13])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1