Hydrochloric Acid → HCID 68727366, compound

HRID 2092206Notes

Reaction equation

HRID 2092206 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3I)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.C(OC([N:29]1[CH2:36][C@@H:35]2[C@@H:31]([CH2:32][NH:33][CH2:34]2)[CH2:30]1)=O)(C)(C)C.[ClH:37]>>[ClH:37].[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3[N:29]2[CH2:36][C@@H:35]3[C@@H:31]([CH2:32][NH:33][CH2:34]3)[CH2:30]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 1514452Cis-2-boc-hexahydropyrrolo[3,4-C]pyrroleHCID 673141573-(3-Fluorophenylsulfonyl)-8-iodoquinoline

Product 1

HCID 68727366HCID 68727366, compound

Procedure

0.145 g of 3-(3-Fluoro-benzenesulfonyl)-8-(3aR,6aS)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl-quinoline hydrochloride were prepared by analogy to the methods of Examples 27 and 28 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with commercially available (3aR,6aS)-Hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester and subsequent deprotection of the tert-butyl-oxycarbonyl derivative with HCl in isoproanol.

Sources & evidence

ORD record
ord-2fa5d3e13144444593feb65c5ee83753
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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