HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 68728638, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(3-Fluorophenylsulfonyl)-8-iodoquinoline | HCID 67314157 | — |
| Reactant | tert-Butyl hexahydro-1H-pyrrolo[3,4-b]pyridine-6(2H)-carboxylate | HCID 68729079 | — |
| Product | HCID 68728638 | HCID 68728638 | — |
Reaction Steps
0.073 g of 6-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-ium chloride were prepared by analogy to the methods of Examples 27 and 28 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with commercially available octahydro-pyrrolo[3,4-b]pyridine-6-carboxylic acid tert-butyl ester and subsequent deprotection of the tert-butyl-oxycarbonyl derivative with HCl in isoproanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440694B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-d61236e335af4030929f4b8718017c44 |
| Source note | uspto-grants-2013_05 |