Hydrochloric Acid → HCID 68728638, compound

HRID 2092207Notes

Reaction equation

HRID 2092207 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3I)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.C(OC([N:29]1[CH2:37][CH:36]2[CH:31]([NH:32][CH2:33][CH2:34][CH2:35]2)[CH2:30]1)=O)(C)(C)C.[ClH:38]>>[Cl-:38].[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3[N:29]2[CH2:37][CH:36]3[CH:31]([NH2+:32][CH2:33][CH2:34][CH2:35]3)[CH2:30]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 673141573-(3-Fluorophenylsulfonyl)-8-iodoquinolineHCID 68729079tert-Butyl hexahydro-1H-pyrrolo[3,4-b]pyridine-6(2H)-carboxylate

Product 1

HCID 68728638HCID 68728638, compound

Procedure

0.073 g of 6-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-ium chloride were prepared by analogy to the methods of Examples 27 and 28 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with commercially available octahydro-pyrrolo[3,4-b]pyridine-6-carboxylic acid tert-butyl ester and subsequent deprotection of the tert-butyl-oxycarbonyl derivative with HCl in isoproanol.

Sources & evidence

ORD record
ord-d61236e335af4030929f4b8718017c44
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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