HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-Hydrazino-butan-2-ol → (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3,4-difluoro-phenylamino)-[1,2,4]triazol-1-yl]-butan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-Hydrazino-butan-2-ol | HCID 28082624 | — |
| Reactant | 1-(2-Chloro-6-methyl-pyridine-4-carbonyl)-3-(3,4-difluoro-phenyl)-2-methyl-isothiourea | HCID 136116018 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | (S)-1-[5-(2-Chloro-6-methyl-pyridin-4-yl)-3-(3,4-difluoro-phenylamino)-[1,2,4]triazol-1-yl]-butan-2-ol | HCID 86644737 | — |
Reaction Steps
Intermediate D2 (1 g; 2.81 mmol) was dissolved in t-BuOH (40 ml) and, then intermediate D3 (0.44 g; 4.22 mmol) was added. The reaction mixture was stirred and refluxed for 4 hours and then the solvent was evaporated. The residue was purified by silica column chromatography (gradient: CH2Cl2/10% CH3OH in CH2Cl2 from 100/0 to 0/100). Yield: 1.1 g of intermediate D4 (S-enantiomer).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440701B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-5cad52bd32f44315ac6e48f044a984ec |
| Source note | uspto-grants-2013_05 |