反应详情

温度

0 °C

46 mg (1.22 mmol) of lithium aluminum hydride are initially charged in 8.0 ml of THF and cooled to 0° C. A solution of 161 mg (0.61 mmol) of the compound from Example 26A in 2.5 ml of THF is then added dropwise. The mixture is stirred at RT for 2 h. The reaction solution is then once more cooled to 0° C., and 0.2 ml of water and 0.4 ml of 1 N aqueous sodium hydroxide solution are added. The mixture is stirred at RT overnight. The precipitate formed is filtered off, and the filtrate is freed from the solvent using a rotary evaporator. The residue is used without further purification in the subsequent reaction.

1. temperatureThe reaction solution is then once more cooled to 0° C.
2. stirringThe mixture is stirred at RT overnight
3. customThe precipitate formed
4. filtrationis filtered off
5. customa rotary evaporator
6. customThe residue is used without further purification in the subsequent reaction