Formamide → 8-Iodo-7-methylquinazolin-4(3H)-one
Reaction equation
[NH2:1][C:2]1[C:10]([I:11])=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>CN1C(=O)CCC1>[I:11][C:10]1[C:9]([CH3:12])=[CH:8][CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 210 °C
Procedure
2-Amino-3-iodo-4-methylbenzoic acid (8.00 g, 29 mmol), formamide (11 mL, 289 mmol) and NMP (11 ml) were added to an 80 mL microwave vessel. The mixture was heated for 15 min at 210° C. The mixture was diluted with ice water and the precipitated solid collected by filtration. The solid was washed with water and dried to give 8-iodo-7-methylquinazolin-4(3H)-one (7.3 g, 88%) as a light brown solid. MS (M+H)+ 287.
Workup
- filtrationthe precipitated solid collected by filtration
- washThe solid was washed with water
- customdried
Sources & evidence
- ORD record
- ord-a3d0e29a87574f98842455b8ccb15988
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08440674B2
Reaction notes
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