(3-Chlorophenyl)(3-fluorophenyl)methanol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-chloro-phenyl)-(3-fluoro-phenyl)-methyl ester

HRID 2092367Notes

Reaction equation

HRID 2092367 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[Cl:17][C:18]1[CH:19]=[C:20]([CH:24]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)[OH:25])[CH:21]=[CH:22][CH:23]=1>>[Cl:17][C:18]1[CH:19]=[C:20]([CH:24]([O:25][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([F:32])[CH:27]=2)[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 2757532(3-Chlorophenyl)(3-fluorophenyl)methanolHCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 86638971Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-chloro-phenyl)-(3-fluoro-phenyl)-methyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3-chloro-phenyl)-(3-fluoro-phenyl)-methanol.

Sources & evidence

ORD record
ord-235be146015d4c8ab41f53b7b6977852
Source dataset
uspto-grants-2013_05
Patent number
US08440690B2

Reaction notes

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