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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2092367Generated: October 31, 2026

(3-Chlorophenyl)(3-fluorophenyl)methanol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-chloro-phenyl)-(3-fluoro-phenyl)-methyl ester

https://huagongshe.com/reaction/2092367

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Chlorophenyl)(3-fluorophenyl)methanolHCID 2757532—
Reactantimidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl esterHCID 59187189—
ProductCarbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3-chloro-phenyl)-(3-fluoro-phenyl)-methyl esterHCID 86638971—

Reaction Steps

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3-chloro-phenyl)-(3-fluoro-phenyl)-methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08440690B2
Source datasetuspto-grants-2013_05
ORD IDord-235be146015d4c8ab41f53b7b6977852
Source noteuspto-grants-2013_05