(3,4-Difluorophenyl)(phenyl)methanol → Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3,4-difluoro-phenyl)-phenyl-methyl ester

HRID 2092372Notes

Reaction equation

[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](N1C=CN=C1)=[O:11])[CH2:2]2.[F:17][C:18]1[CH:19]=[C:20]([CH:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[OH:26])[CH:21]=[CH:22][C:23]=1[F:24]>>[F:17][C:18]1[CH:19]=[C:20]([CH:25]([O:26][C:10](=[O:11])[O:9][C@@H:3]2[CH:4]3[CH2:5][CH2:6][N:1]([CH2:8][CH2:7]3)[CH2:2]2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=[CH:22][C:23]=1[F:24]

Participants

Reactant 2

HCID 2758251(3,4-Difluorophenyl)(phenyl)methanol

HCID 59187189imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester

Product 1

HCID 86638976Carbonic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (3,4-difluoro-phenyl)-phenyl-methyl ester

Procedure

The desired product was prepared by reacting imidazole-1-carboxylic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester with (3,4-difluoro-phenyl)-phenyl-methanol.

Sources & evidence

ORD record: ord-48e489f708934b72a162e41151d7051d
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08440690B2

Reaction notes

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