Lithium Hydroxide → 5-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid

HRID 2092409Notes

Reaction equation

HRID 2092409 reaction equation
[OH-].[Li+].C[O:4][C:5]([C:7]1[C:8]([CH3:19])=[N:9][O:10][C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)=[O:6]>CO.O>[Br:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]2[O:10][N:9]=[C:8]([CH3:19])[C:7]=2[C:5]([OH:6])=[O:4])=[CH:17][CH:16]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 56604575Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

Product 1

HCID 566045595-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

Lithium hydroxide (2 g, 48 mmol) was added to a solution of 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (39 mmol) in methanol (50 mL) and water (10 mL), and the reaction was stirred at 60° C. for 1 hour. Acidic work-up gave the title compound.

Sources & evidence

ORD record
ord-8eda3f9e32454c06925a27b63e342f85
Source dataset
uspto-grants-2013_05
Patent number
US08440707B2

Reaction notes

Loading…