Ethanol → Ethyl 2-(3-bromo-4-fluorophenyl)acetate

HRID 2092413Notes

Reaction equation

HRID 2092413 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[F:8].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH2:18]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 34163393-Bromo-4-fluorophenylacetic Acid

Product 1

HCID 58539475Ethyl 2-(3-bromo-4-fluorophenyl)acetate

Procedure

3-Bromo-4-fluorophenylacetic acid (2.35 g, 9.0 mmol) was treated with concentrated sulfuric acid (2 mL) in ethanol (100 mL) at reflux for 2 hours. Purification by silica gel chromatography provided the title compound.

Workup

  1. temperatureat reflux for 2 hours
  2. customPurification by silica gel chromatography

Sources & evidence

ORD record
ord-c27a18d723cd4e3aa4a3be4aa1d94693
Source dataset
uspto-grants-2013_05
Patent number
US08440707B2

Reaction notes

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