反应详情

温度

195 °C

To a 250 mL round bottom flask, 2-amino-4-bromo-benzoic acid (10 g, 0.0463 mol) and urea (27.78 g, 0.4629 mol) were added. The reaction mixture was stirred at 195° C. for 3 h. The reaction mixture was allowed to reach 80° C. and water was added. The aqueous reaction mixture was stirred at 80° C. for 5-10 min then allowed to reach room temperature. The solid was filtered, dried and azeotroped with toluene to afford the title compound [10 g, 90%]. This material was taken to the next step without any further purification.

1. customto reach 80° C.
2. stirringThe aqueous reaction mixture was stirred at 80° C. for 5-10 min
3. customto reach room temperature
4. filtrationThe solid was filtered
5. customdried
6. customazeotroped with toluene