Urea → HCID 178518404, compound

HRID 2092560Notes

Reaction equation

HRID 2092560 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[NH2:12][C:13](N)=[O:14]>O>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[C:9]([OH:11])=[N:12][C:13]([OH:14])=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 497615813-Amino-5-bromopyridine-2-carboxylic acid

Product 1

HCID 178518404HCID 178518404, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
200 °C

Procedure

To a 100 mL round bottom flask, 3-amino-5-bromo-pyridine-2-carboxylic acid (1 g, 0.0046 mol) and urea (2.768 g, 0.4629 mol) were added. The reaction mixture was stirred at 200° C. for 2.5 h. The reaction mixture was cooled, water was added and stirred to provide a precipitate. The precipitate was filtered and dried to provide the title compound [1 g, 91%]. This material was taken to the next step without any further purification.

Workup

  1. temperatureThe reaction mixture was cooled
  2. stirringstirred
  3. customto provide a precipitate
  4. filtrationThe precipitate was filtered
  5. customdried

Sources & evidence

ORD record
ord-0695f461d8c44f63bdd3746763f97f28
Source dataset
uspto-grants-2013_05
Patent number
US08440662B2

Reaction notes

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