p-Fluoronitrobenzene → 4-((S)-2,2,2-Trifluoro-1-methyl-ethoxy)-phenylamine

HRID 2092681Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C@@H:3]([OH:5])[CH3:4].F[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1>>[F:1][C:2]([F:7])([F:6])[C@H:3]([CH3:4])[O:5][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 9590p-Fluoronitrobenzene

HCID 6999971(2S)-1,1,1-Trifluoropropan-2-ol

Product 1

HCID 665798964-((S)-2,2,2-Trifluoro-1-methyl-ethoxy)-phenylamine

Procedure

This material was made in analogy to example 142, step 1 from (S)-1,1,1-trifluoro-2-propanol [CAS 17628-73-8] and 1-fluoro-4-nitro-benzene [CAS 350-46-9]. MS (m/e): 206.1 (MH+).

Sources & evidence

ORD record: ord-96d594fab5cb44d59964c6a8438523c2
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08440710B2

Reaction notes

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