HCID 66580148, compound → HCID 66580033, compound

HRID 2092684Notes

Reaction equation

HRID 2092684 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][C@@H:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[N:8][CH:9]=1)([O-])=O.[H][H]>[Pd].CO>[F:15][C:12]([F:13])([F:14])[C@H:11]([CH3:16])[O:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 66580148HCID 66580148, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66580033HCID 66580033, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Nitro-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine (81.9 g) and palladium on carbon (10% Pd, 0.0065 mol-eq) were added to MeOH and the mixture was hydrogenated until uptake of hydrogen was ceasing. The catalyst was removed by filtration and the filtrate was concentrated and further dried in vacuo to provide the title compound as a dark oil. MS (m/e): 207.0 (MH+).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customfurther dried in vacuo

Sources & evidence

ORD record
ord-371b6ecdd75949e5a7c6cc3354e4dad7
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

Loading…