HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66580148, compound → HCID 66580033, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66580148 | HCID 66580148 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 66580033 | HCID 66580033 | — |
Reaction Steps
5-Nitro-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine (81.9 g) and palladium on carbon (10% Pd, 0.0065 mol-eq) were added to MeOH and the mixture was hydrogenated until uptake of hydrogen was ceasing. The catalyst was removed by filtration and the filtrate was concentrated and further dried in vacuo to provide the title compound as a dark oil. MS (m/e): 207.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440710B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-371b6ecdd75949e5a7c6cc3354e4dad7 |
| Source note | uspto-grants-2013_05 |