HCID 58230115, compound → HCID 66579360, compound

HRID 2092688Notes

Reaction equation

HRID 2092688 reaction equation
[OH:1][CH:2]1[CH2:25][CH2:24][C:5]2([C:9](=[O:10])[N:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH:18]([CH3:23])[C:19]([F:22])([F:21])[F:20])=[CH:13][CH:12]=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3]1>CCOCC.CCCCCCC>[F:22][C:19]([F:20])([F:21])[CH:18]([CH3:23])[O:17][C:14]1[CH:15]=[CH:16][C:11]([N:8]2[CH2:7][CH2:6][C:5]3([CH2:4][CH2:3][C:2](=[O:1])[CH2:25][CH2:24]3)[C:9]2=[O:10])=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 58230115HCID 58230115, compound

Product 1

HCID 66579360HCID 66579360, compound

Reagents, catalysts & solvents 1

HCID 21897273Diethylether heptaneSolvent

Procedure

This material was obtained in analogy to example 108, step 4 by Swern oxidation of 8-hydroxy-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2-aza-spiro[4.5]decan-1-one (230 mg, obtained in example 162, step 3) as a colorless solid (230 mg). Rf: 0.3 (silica gel, ether/heptane 1:1).

Sources & evidence

ORD record
ord-03b123ce6ea24c3c90991cf865f2bb6a
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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