1,4-Dioxa-10-azadispiro[4.2.4.2]tetradecan-9-one → HCID 66580350, compound

HRID 2092707Notes

Reaction equation

HRID 2092707 reaction equation
[O:1]1[C:5]2([CH2:15][CH2:14][C:8]3([CH2:12][CH2:11][NH:10][C:9]3=[O:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Br[C:17]1[CH:22]=[CH:21][C:20]([CH:23]2[CH2:26][C:25]([F:28])([F:27])[CH2:24]2)=[CH:19][CH:18]=1>>[F:27][C:25]1([F:28])[CH2:24][CH:23]([C:20]2[CH:19]=[CH:18][C:17]([N:10]3[CH2:11][CH2:12][C:8]4([CH2:14][CH2:15][C:5]5([O:4][CH2:3][CH2:2][O:1]5)[CH2:6][CH2:7]4)[C:9]3=[O:13])=[CH:22][CH:21]=2)[CH2:26]1

Participants

3

Reactant 2

HCID 582301081,4-Dioxa-10-azadispiro[4.2.4.2]tetradecan-9-oneHCID 594408571-Bromo-4-(3,3-difluorocyclobutyl)benzene

Product 1

HCID 66580350HCID 66580350, compound

Procedure

The title compound was prepared in analogy to example 336, step 1 from 1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (described in example 133, step 3, 165 mg) and 1-bromo-4-(3,3-difluoro-cyclobutyl)-benzene (193 mg, described above). White solid (270 mg, 70%). MS (m/e): 378.3 [MH+].

Sources & evidence

ORD record
ord-3721f1426110414983270a3590dc639e
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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