1-Bromo-4-tert-butylbenzene → 10-(4-tert-Butyl-phenyl)-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

HRID 2092709Notes

Reaction equation

HRID 2092709 reaction equation
[O:1]1[C:5]2([CH2:15][CH2:14][C:8]3([CH2:12][CH2:11][NH:10][C:9]3=[O:13])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.Br[C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:19][CH:18]=1>>[C:23]([C:20]1[CH:21]=[CH:22][C:17]([N:10]2[CH2:11][CH2:12][C:8]3([CH2:14][CH2:15][C:5]4([O:4][CH2:3][CH2:2][O:1]4)[CH2:6][CH2:7]3)[C:9]2=[O:13])=[CH:18][CH:19]=1)([CH3:26])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 775951-Bromo-4-tert-butylbenzeneHCID 582301081,4-Dioxa-10-azadispiro[4.2.4.2]tetradecan-9-one

Product 1

HCID 6657950810-(4-tert-Butyl-phenyl)-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Procedure

The title compound was prepared in analogy to example 336, step 1 from 1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (described in example 133, step 3) and 1-bromo-4-tert-butyl-benzene. White solid (84%). MS (m/e): 344.2 [MH+].

Sources & evidence

ORD record
ord-51e669bc5a7b4ac0882d3609b92feeae
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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