Tetrahydrofuran → 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)-2-fluorophenyl)-3-(3-(2-fluoropropan-2-yl)isoxazol-5-yl)urea
Reaction equation
[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:21][O:22][c:23]1[cH:24][c:25]2[c:26]([O:35][c:36]3[c:37]([F:43])[c:38]([NH2:39])[cH:40][cH:41][cH:42]3)[n:27][cH:28][n:29][c:30]2[cH:31][c:32]1[O:33][CH3:34].[F:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([NH:10][C:11]([O:12][c:13]2[cH:14][cH:15][c:16]([Cl:17])[cH:18][cH:19]2)=[O:20])[cH:9]1>>[F:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([NH:10][C:11](=[O:20])[NH:39][c:38]2[c:37]([F:43])[c:36]([O:35][c:26]3[c:25]4[cH:24][c:23]([O:22][CH3:21])[c:32]([O:33][CH3:34])[cH:31][c:30]4[n:29][cH:28][n:27]3)[cH:42][cH:41][cH:40]2)[cH:9]1Participants
4
Sources & evidence
- ORD record
- ord-5fdf8975ecf74a29935cec686f15663d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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