反应详情

To a flask containing methyl 6-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexyl-amino)-4-cyano-2-(1-ethyl-1H-pyrazol-4-yl)nicotinate (62 mg, 0.132 mmol) in MeOH (2 mL) was added HOAc (1 mL) to give a yellow solution. Palladium on carbon was added (14.08 mg, 0.132 mmol). The flask was evacuated and filled with H2 three times, after which the mixture was stirred vigorously at RT under a H2 atmosphere overnight. The mixture was filtered through Celite, and the solvent was removed in vacuo to give a residue, which was dissolved in DCM (10 mL) and MeOH (10 mL). Potassium carbonate was added and the mixture was stirred for 5 h. The solids were filtered out and the filtrate concentrated to give the title compound (50 mg, 86%). [M+H] calc'd for C23H32N6O3, 441. found, 441.

1. customto give a yellow solution
2. customThe flask was evacuated
3. additionfilled with H2 three times
4. filtrationThe mixture was filtered through Celite
5. customthe solvent was removed in vacuo
6. customto give a residue, which
7. stirringthe mixture was stirred for 5 h
8. filtrationThe solids were filtered out
9. concentrationthe filtrate concentrated