Levodopa → L-Phenylalanine

HRID 2092920Notes

Reaction equation

HRID 2092920 reaction equation
[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.N[C@H](C(O)=O)CC1C=CC(O)=CC=1.N[C@@H](C(O)=O)[C@H](C)O.O=C([C@H](CC1C=C(O)C(O)=CC=1)N)O.C1NC=NC=1C[C@@H](N)C(O)=O.N[C@H](C(O)=O)CC1C2C(=CC=CC=2)NC=1.C1C=CC2NC=C(C[C@@H](N)C(O)=O)C=2C=1.C1(C2N[C@H](C(O)=O)CC2)C=CC=CC=1>>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

9

Reactant 8

HCID 6047LevodopaHCID 6057L-TyrosineHCID 6305L-TryptophanHCID 9060D-TryptophanHCID 69435D-ThreonineHCID 71567D-PhenylalanineHCID 533933635-Phenylproline2×HCID 178511802D-Histidine

Product 1

HCID 6140L-Phenylalanine

Procedure

replace with: D-Phe, Tyr, D-Thr, L-Dopa, His, D-His, Trp, D-Trp, Trans-3, 4 or 5-phenylproline, cis-3, 4, or 5-phenylproline;

Sources & evidence

ORD record
ord-f1c0bc034df0405dbbc214486b69b799
Source dataset
uspto-grants-2013_05
Patent number
US08440795B2

Reaction notes

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