反应详情

38.7 g of (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanamide (S)-mandelic acid salt are suspended in 500 ml of isopropyl acetate and admixed with 11.8 g of 37% hydrochloric acid. After stirring at room temperature for 1 h, half of the solvent is distilled off in vacuo and replaced by fresh isopropyl acetate. After this has been repeated once more, the mixture is heated to 60° C., and the solid is filtered off and washed with warm isopropyl acetate. 25.0 g of (2S,3S)-N-cyclopropyl-3-amino-2-hydroxyhexanamide hydrochloride are obtained.

1. distillationhalf of the solvent is distilled off in vacuo
2. temperaturethe mixture is heated to 60° C.
3. filtrationthe solid is filtered off
4. washwashed with warm isopropyl acetate