P-Anisidine → 13519-16-9

HRID 2093059Notes

Reaction equation

HRID 2093059 reaction equation
[C:1](Br)#[N:2].[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1>C(OCC)C>[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:1]#[N:2])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 10476Cyanogen Bromide

Product 1

HCID 1093158813519-16-9

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of cyanobromide (0.6 eq) in diethyl ether, a solution of 4-methoxy phenyl amine (1.0 eq) in diethyl ether was added and the reaction mixture was stirred at room temperature for 2 h. Salt separated out was filtered and the filtrate was concentrated to afford the desired 4-methoxy-phenyl-cyanamide in good yield.

Workup

  1. customSalt separated out
  2. filtrationwas filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-eea254c454994d64aea3c0a4af727066
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

Loading…