Water → HCID 178503854, compound

HRID 2093065Notes

Reaction equation

HRID 2093065 reaction equation
[CH3:1][S:2]/[C:3](=[N:18]\[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)/[N:4]1[CH2:9][CH2:8][C:7]2[N:10]=[C:11]([C:13]([O:15]CC)=[O:14])[S:12][C:6]=2[CH2:5]1.C([O-])([O-])=O.[K+].[K+].O>CO>[CH3:1][S:2]/[C:3](=[N:18]\[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)/[N:4]1[CH2:9][CH2:8][C:7]2[N:10]=[C:11]([C:13]([OH:15])=[O:14])[S:12][C:6]=2[CH2:5]1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 178470168HCID 178470168, compound

Product 1

HCID 178503854HCID 178503854, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of ethyl 5-[(Z)-(methylthio)(phenylimino)methyl]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylate (1 eq) obtained in step II in methanol, K2CO3 (2 eq) and few drops of water were added and the reaction mixture was stirred at room temperature for 15 h. Solvent was evaporated and the residue was treated with etheral HCl. The solvent was then evaporated and the residue was as such used for further reaction without purification.

Workup

  1. customSolvent was evaporated
  2. additionthe residue was treated with etheral HCl
  3. customThe solvent was then evaporated
  4. customas such used for further reaction without purification

Sources & evidence

ORD record
ord-508e57b2b6ac41bdb2c5fd81f3ea5775
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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