Cyanamide → HCID 178492350, compound

HRID 2093069Notes

Reaction equation

HRID 2093069 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:10]=1[NH:17][C:18]([C:20]1[S:21][C:22]2[CH2:23][N:24]([C:29](SC)=[N:30][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:25][CH2:26][C:27]=2[N:28]=1)=[O:19])=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:39]#[C:40][NH2:41]>C1COCC1>[C:40]([NH:41]/[C:29](=[N:30]\[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)/[N:24]1[CH2:25][CH2:26][C:27]2[N:28]=[C:20]([C:18]([NH:17][C:10]3[CH:11]=[CH:12][C:13]([O:15][CH3:16])=[CH:14][C:9]=3[NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:19])[S:21][C:22]=2[CH2:23]1)#[N:39]

Participants

4

Reactant 2

HCID 9864CyanamideHCID 66864416methyl 2-({2-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl}carbamoyl)-N-phenyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carbimidothioate

Product 1

HCID 178492350HCID 178492350, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl 2-({2-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl}carbamoyl)-N-phenyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carbimidothioate (1 eq) obtained in step I, cyanamide (10 eq) in very small quantity of THF was heated at reflux temperature for 15 h.

Workup

  1. temperatureat reflux temperature for 15 h.

Sources & evidence

ORD record
ord-bda8533fb06d475bb950ddab86f2cac6
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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