反应详情

Methyl chloroformate (1.0 mmol) was added drop wise to N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained from step VIII of example 1 (1.0 mmol) solution in 10 mL of dry DMF at 0° C. Reaction mixture was stirred for additional 3 h Reaction mixture was concentrated, diluted with water, extracted with dichloromethane, washed with brine solution, and dried over anhydrous Na2SO4. Concentrated and purified by column chromatography to get the title compound.

1. customReaction mixture
2. customReaction mixture
3. concentrationwas concentrated
4. additiondiluted with water
5. extractionextracted with dichloromethane
6. washwashed with brine solution
7. dry with materialdried over anhydrous Na2SO4
8. concentrationConcentrated
9. custompurified by column chromatography