Potassium Hydroxide → 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid

HRID 2093089Notes

Reaction equation

HRID 2093089 reaction equation
C([O:3][C:4]([C:6]1[S:14][C:13]2[CH2:12][CH2:11][N:10](C(OCC)=O)[CH2:9][C:8]=2[CH:7]=1)=[O:5])C.[OH-].[K+]>C(O)C>[S:14]1[C:13]2[CH2:12][CH2:11][NH:10][CH2:9][C:8]=2[CH:7]=[C:6]1[C:4]([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14254905Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate

Product 1

HCID 142549064,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester (1 eq) obtained in step III and aq. KOH (3 eq.) in ethanol was refluxed for 48 h Reaction mixture was concentrated under reduced pressure and neutralized to pH 7.0 to get 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid.

Workup

  1. customReaction mixture
  2. concentrationwas concentrated under reduced pressure and neutralized to pH 7.0

Sources & evidence

ORD record
ord-035aa71364fd4ab484f0f1123621bd19
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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