HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate | HCID 14254905 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid | HCID 14254906 | — |
Reaction Steps
A solution of 6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester (1 eq) obtained in step III and aq. KOH (3 eq.) in ethanol was refluxed for 48 h Reaction mixture was concentrated under reduced pressure and neutralized to pH 7.0 to get 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-035aa71364fd4ab484f0f1123621bd19 |
| Source note | uspto-grants-2013_05 |