HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → tert-butyl 4,5-Dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | (2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester | HCID 19600076 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | tert-butyl 4,5-Dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate | HCID 17389936 | — |
Reaction Steps
To a solution of tert-butyl[2-(3-thienyl)ethyl]carbamate in toluene was added paraformaldehyde (2 equi.) and catalytic amount of PTSA and reaction mixture was then refluxed in dean stark apparatus for 4 hrs. Reaction mass wan then concentrated and extracted with dichloromethane dried over sodium sulphate and evaporated to yield tert-butyl 4,7-dihydrothieno[2,3-c]pyridine-6(5H)— carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-b043a35771784d9eb6582b7dc61ab5b2 |
| Source note | uspto-grants-2013_05 |