反应详情

To a solution of tert-butyl[2-(3-thienyl)ethyl]carbamate in toluene was added paraformaldehyde (2 equi.) and catalytic amount of PTSA and reaction mixture was then refluxed in dean stark apparatus for 4 hrs. Reaction mass wan then concentrated and extracted with dichloromethane dried over sodium sulphate and evaporated to yield tert-butyl 4,7-dihydrothieno[2,3-c]pyridine-6(5H)— carboxylate.

1. temperaturewas then refluxed in dean stark apparatus for 4 hrs
2. customReaction mass
3. concentrationwan then concentrated
4. extractionextracted with dichloromethane
5. dry with materialdried over sodium sulphate
6. customevaporated