HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093103Generated: October 31, 2026
4-Methylmorpholine → N-(2-aminophenyl)-6-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide
https://huagongshe.com/reaction/2093103
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 2-(3-Methoxyphenoxy)acetic acid | HCID 74969 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-(2-aminophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide | HCID 58117017 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-aminophenyl)-6-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide | HCID 25230273 | — |
Reaction Steps
To the solution of (3-Methoxy-phenoxy)-acetic acid (1.0 mmol) in dry DMF (10 mL), were added 1-hydroxybenzotriazole (1.2 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (2 mmol) and N-methylmorpholine (2.0 mmol). Solution was cooled to 0° C. N-(2-aminophenyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide (1.0 eq) obtained in step VII of example 216 was then added and mixture was stirred at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440830B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-3049a59f7eeb437582f87092e7118c7c |
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| Source note | uspto-grants-2013_05 |
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