Tetrahydrofuran → 5-[6-Oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]-1,3-dihydrobenzimidazol-2-one

HRID 2093352Notes

Reaction equation

HRID 2093352 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[NH2:25])[CH2:5][N:6]1[C:11](=[O:12])[CH:10]=[CH:9][C:8]([C:13]2[CH:18]=[C:17]([F:19])[C:16]([F:20])=[C:15]([F:21])[CH:14]=2)=[N:7]1.C1C[O:29][CH2:28]C1>>[O:12]=[C:11]1[N:6]([CH2:5][C:4]2[CH:22]=[CH:23][C:24]3[NH:25][C:28](=[O:29])[NH:1][C:2]=3[CH:3]=2)[N:7]=[C:8]([C:13]2[CH:14]=[C:15]([F:21])[C:16]([F:20])=[C:17]([F:19])[CH:18]=2)[CH:9]=[CH:10]1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 594068152-(3,4-Diaminobenzyl)-6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one

Product 1

HCID 594068205-[6-Oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]-1,3-dihydrobenzimidazol-2-one

Procedure

1 g (2.89 mmol) of 2-(3,4-diaminobenzyl)-6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one are dissolved in 10 ml of THF, 702 mg (4.33 mmol) of 1,1″-carbonyldiimidazole (CDI) are added, and the mixture is stirred at room temperature. After 15 h, the precipitate formed is filtered off with suction, washed with THF and dried in vacuo.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off with suction
  3. washwashed with THF
  4. customdried in vacuo

Sources & evidence

ORD record
ord-b71165f926864cddbcd874bae5786c72
Source dataset
uspto-grants-2013_05
Patent number
US08445489B2

Reaction notes

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