HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2,2,2-Trichloroethyl 4,4-difluorocyclohexylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,2,2-Trichloroethyl chloroformate | HCID 87063 | — |
| Reactant | 4,4-Difluorocyclohexan-1-amine hydrochloride | HCID 23150669 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,2,2-Trichloroethyl 4,4-difluorocyclohexylcarbamate | HCID 58359242 | — |
Reaction Steps
4,4-difluorocyclohexylamine hydrochloride (8) is acylated with 2,2,2-trichloroethyl carbonochloridate (9) using an organic base such as triethylamine in an inert solvent such as dichloromethane to give 2,2,2-trichloroethyl 4,4-difluorocyclohexylcarbamate, (7), Step 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445493B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-56adf19c63d745718996ae4df994d86d |
| Source note | uspto-grants-2013_05 |