1-(Methylsulfonyl)piperazine → HCID 44545388, compound

HRID 2093402Notes

Reaction equation

HRID 2093402 reaction equation
C(OC([NH:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[N:23]=[C:22]3[C:18]([N:19]=[CH:20][N:21]3[CH2:24][C:25](O)=[O:26])=[C:17]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[N:16]=2)=[CH:11][N:10]=1)=O)(C)(C)C.[CH3:34][S:35]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)(=[O:37])=[O:36]>>[NH2:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[N:23]=[C:22]3[C:18]([N:19]=[CH:20][N:21]3[CH2:24][C:25]([N:41]3[CH2:42][CH2:43][N:38]([S:35]([CH3:34])(=[O:37])=[O:36])[CH2:39][CH2:40]3)=[O:26])=[C:17]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[N:16]=2)=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 58015218HCID 58015218, compound

Product 1

HCID 44545388HCID 44545388, compound

Procedure

2-(2-(2-(tert-butoxycarbonylamino)pyrimidin-5-yl)-6-morpholino-9H-purin-9-yl)acetic acid (35 mg) was reacted with 1-(methylsulfonyl)piperazine via General Procedure E followed by Boc deprotection via General Procedure D and purified via reverse phase HPLC to give 9 mg 123 as a white solid. MS (Q1) 503.2 (M)+.

Workup

  1. custompurified via reverse phase HPLC

Sources & evidence

ORD record
ord-086436cb94ea41048ad5c1e03d5f32f5
Source dataset
uspto-grants-2013_05
Patent number
US08445487B2

Reaction notes

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