p-Toluenesulfonic acid → HCID 178504958, compound

HRID 2093413Notes

Reaction equation

HRID 2093413 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:17][N:18]3[CH2:23][CH2:22][N:21]([S:24]([CH3:27])(=[O:26])=[O:25])[CH2:20][CH2:19]3)[N:8]2C2CCCCO2)=[C:4]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[N:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([CH2:17][N:18]3[CH2:19][CH2:20][N:21]([S:24]([CH3:27])(=[O:25])=[O:26])[CH2:22][CH2:23]3)[NH:8]2)=[C:4]([N:28]2[CH2:29][CH2:30][O:31][CH2:32][CH2:33]2)[N:3]=1

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 86637240HCID 86637240, compound

Product 1

HCID 178504958HCID 178504958, compound

Procedure

4-(2-chloro-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)morpholine (250 mg) was treated with para-toluenesulfonic acid via General Procedure D to give 4-(2-chloro-8-((4-(methylsulfonyl)piperazin-1-yl)methyl)-9H-purin-6-yl)morpholine.

Sources & evidence

ORD record
ord-f6c1e53bb2af40c4b06f33b933bd7161
Source dataset
uspto-grants-2013_05
Patent number
US08445487B2

Reaction notes

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