Trifluoroacetic acid → HCID 59178900, compound

HRID 2093476Notes

Reaction equation

HRID 2093476 reaction equation
[F:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][CH:12]([CH:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[N:4][C:5]([CH3:8])=[N:6][CH:7]=1.C(O)(C(F)(F)F)=O>>[F:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][CH:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[CH2:11][CH2:10]2)=[N:4][C:5]([CH3:8])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59178826HCID 59178826, compound

Product 1

HCID 59178900HCID 59178900, compound

Procedure

The tert-butyl 1′-(5-fluoro-2-methylpyrimidin-4-yl)-4,4′-bipiperidine-1-carboxylate (22 mg, 0.058 mmol) was mixed with 0.2 mL of TFA and stirred at r.t. for 5 min and was concentrated on rotavapor to yield title compound and was used directly for next step.

Workup

  1. concentrationwas concentrated on rotavapor

Sources & evidence

ORD record
ord-44631d0a7d1840faba8a2a7602450a4e
Source dataset
uspto-grants-2013_05
Patent number
US08445499B2

Reaction notes

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