反应详情

The above 3-chloro-4-methoxy-2,5-dimethylpyridine 1-oxide (530 mg) was suspended in 15 ml of dichloromethane, and trifluoroacetic anhydride (0.39 ml) was then added to the suspension under cooling on ice. The resulting mixture was stirred at room temperature for 3 hours. The reaction solution was diluted with chloroform, and was then washed with a saturated sodium bicarbonate solution. The water layer was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then distilled away, so as to obtain the title compound (521 mg) as an oily substance.

1. temperatureunder cooling on ice
2. washwas then washed with a saturated sodium bicarbonate solution
3. extractionThe water layer was extracted with chloroform
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. distillationthe solvent was then distilled away