tert-Butyl 2-(aminomethyl)morpholine-4-carboxylate → tert-Butyl 2-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)morpholine-4-carboxylate

HRID 2093604Notes

Reaction equation

HRID 2093604 reaction equation
[NH2:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]1.[C:16]([C:18]1[CH:19]=[C:20]([CH:36]([CH3:38])[CH3:37])[C:21]2[O:25][C:24]([C:26]3[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=3)=[N:23][C:22]=2[CH:35]=1)#[N:17]>>[C:16]([C:18]1[CH:19]=[C:20]([CH:36]([CH3:38])[CH3:37])[C:21]2[O:25][C:24]([C:26]3[CH:34]=[CH:33][C:29]([C:30]([NH:1][CH2:2][CH:3]4[O:8][CH2:7][CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:4]4)=[O:31])=[CH:28][CH:27]=3)=[N:23][C:22]=2[CH:35]=1)#[N:17]

Participants

3

Reactant 2

HCID 19081094tert-Butyl 2-(aminomethyl)morpholine-4-carboxylateHCID 573699454-(5-Cyano-7-isopropylbenzo[d]oxazol-2-yl)benzoic acid2×

Product 1

HCID 59586039tert-Butyl 2-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)morpholine-4-carboxylate

Procedure

The title compound was then prepared from tert-butyl 2-(aminomethyl)morpholine-4-carboxylate (48 mg) and 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoic acid, INTERMEDIATE 2) as described in EXAMPLE 35. Mass spectrum (ESI) 505.3 (M+1).

Sources & evidence

ORD record
ord-a854a945614e4bfebd069fca354a5925
Source dataset
uspto-grants-2013_05
Patent number
US08445480B2

Reaction notes

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